FEATURES OF THE FORMATION OF ANTIENDOTOXIC IMMUNITY AGAINST ENDOTOXINS OF GRAM-NEGATIVE BACTERIA

Abstract

Relevance. The identification and evaluation of antiendotoxic immunity in inflammatory diseases of bacterial etiology is of critical importance for determining the early diagnosis of these diseases, the prospect of the end of the disease. These obtained results suggest that the creation of clinical-immunological criteria to prevent the transition of diseases of bacterial etiology among children to chronic manifestations increases the educational value of antiendotoxic immunity. On a global scale, the endotoxins of Gram-negative bacteria today, their induction of the synthesis of various cytokines and other mediators upon landing in the human body, the absence of organotropy of endotoxins from protein toxins, the property of suppressing the phagocytosis process, the difference in the presence of a non-special effect, received various pathologies and pathogenetic mechanisms of causing pathological conditions were revealed, , the problems of their use for diagnostic purposes remain relevant today, attracting attention in scientific sources with the fact that research work on this problem is rare [1.3.5.7].