Characteristics of Immune System Dysfunction in Patients With Acne and Functional Dyspepsia

Abstract

Inflammation is known to be a very complex mechanism, in the regulation of which pro- and anti-inflammatory cytokines actively participate. This group of biologically active compounds is synthesized in almost all cellular structures of the body, the main task is to coordinate the processes of development, differentiation and proliferation of all immunocompetent cells, their migration to areas of inflammation, antibody synthesis, cytotic activity of all populations of immunocompetent cells, thereby regulating the immune response. The population of proinflammatory cytokines, such as IL-1β, IL-4, IL-6, IL-12, TNF-α. they participate in the regulation at the level of local inflammation. Questions of the role and place of cytokines in the development of acne in patients with PD remain out of sight, it is problematic to understand the mechanism of cytokine status dysfunction. It remains a well-known fact that during the development of cellular and/or humoral immunity, various types of cytokines are also activated. So, after the first stage of activation of T cells, T-dependent and B-lymphocytes, the development of the primary immune response occurs, the implementation of which is carried out by mediators – cytokines.